The Longevity Reporter: The Weekly Newsletter About Aging
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The Causes Of Cancer You Can Control
Can cancer be prevented? Decades of research have shown that a person’s chances of getting cancer depends on a mishmash of their genes and their environment, but also certain aspects of their lives, many of which they can control. 

Calculations based on predicted cases for 2010, show that smoking, diet, alcohol and obesity are behind more than 100,000 cancers. This is equivalent to one third of all cancers diagnosed in the UK each year. And this figure further increases to around 134,000 when taking into account all 14 lifestyle and environmental risk factors analysed in this study.

Read the detailed analysis and download the larger PDF version of the infographic at Cancer Research UK
Five Quick Reads
The Failure Rate Of Clinical Trials For Alzheimer’s Is 99.6%. How Can We Improve This Situation?

Current estimates are that 820,000 people in the UK are affected by dementia and the aging population means that this number is expected to rise to over 2 million by 2050. The economic impact of dementia is enormous, costing the UK £23 Billion a year and £360 Billion worldwide. Dr Simon Ridley, Head of Research at Alzheimer's Research UK, discusses the challenges we are facing in tackling Alzheimer's, and what we can do to address them. Read more
The 3% Solution: Genes, Intelligence And Mitigating Cognitive Decline

Scientists investigating cognitive decline in old age have found a potent source of genetic variation that appears to raise intelligence by the equivalent of six IQ points. The variant, GL-KS, is based on a protein called klotho, which doubles the brain’s memory- and learning-circuits. Many claims about smart genes are flaky; this one seems robust. The finding was reproduced in three studies and tested on mice. Read more
An Inexpensive Multi-Cancer Diagnostic?

Researchers report an ability to detect several types of cancer in blood samples based on signatures of immune response, but some are skeptical about the utility of such a test. The researchers created an inexpensive blood test that can detect several common cancers based on the immune responses they evoke. They used arrays of randomly generated peptides to bind antibodies from human blood samples belonging either to healthy controls or to people with one of five different cancers. Based on the binding patterns—or immunosignatures—the researchers were able to distinguish between all five cancer types. Read more
Not All Stem Cells Created Equal: Cloned Stem Cells Offer High Fidelity

Scientists have established two ways to take differentiated cells from one person and generate stem cells capable of forming all cell types in the body — most recently by cloning. Research published in Nature Magazine compares genetically identical human stem cells made by different techniques and reveals differences in gene expression that might be important for medical research and for cell therapies. Stem cells made by nuclear transfer seem more faithful to originals than are cells that have been reprogrammed. Read more
Is Animal Research Sufficiently Evidence Based To Be A Cornerstone Of Biomedical Research?

Writing in the BMJ, Yale University epidemiologist Michael Bracken and UK medical sociologist Pandora Pound cite several examples of ultimately futile animal research. They write that decades of stroke studies using animal models have yet to yield a single treatment that is useful for humans. Likewise, they note, not one of the more than 100 drugs that have been tested in a mouse model of amyotrophic lateral sclerosis has proved to be beneficial after further experiments. Read more
Upcoming Events
July 24, 2014Energetics and Human Aging - Professor Greg Tranah speaking about mitochondrial origins to circadian rhythms: how DNA mutations, cellular mechanisms and activity patterns influence longevity

September 23-25, 2014 - MipTec 2014: Europe’s leading event for Drug Discovery and Life Sciences Research

August 21-23, 2014SENS Research Foundation is proud to present the Rejuvenation Biotechnology Conference: Emerging Regenerative Medicine Solutions for the Diseases of Aging. 

October 1, 2014Promoting longevity research on the 1st of October, the UN International Day of Older Persons

October 1-3, 2014
Eurosymposium on Healthy Ageing - A biannual conference that highlights the cutting-edge in the field of biogerontology, while facilitating a unique opportunity for researchers and advocates from around the world to meet.
Read Later
This newsletter was edited by Avi Roy

Copyright © 2014 The Longevity Reporter, All rights reserved.

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