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The Longevity Reporter: The Weekly Newsletter About Aging
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A Call To Prevent Chronic Disease By Treating Aging 
By 2050, the number of people over the age of 80 will triple globally. These demographics could come at great cost to individuals and economies.  Unfortunately, medicine focuses almost entirely on fighting chronic diseases in a piecemeal fashion as symptoms develop, researchers writing in the journal Nature say. Instead, more efforts should be directed to promoting interventions that have the potential to prevent multiple chronic diseases and extend healthy lifespans. 

In a commentary published in Nature, researchers at Washington University School of Medicine in St. Louis, Brescia University in Italy, the Buck Institute for Aging, and Research and the Longevity Institute at the University of Southern California call for moving forward with preclinical and clinical strategies that have been shown to delay aging in animals.

Read the entire call to action at Nature Magazine.
Five Quick Reads
Google X Project Aims To Describe A Healthy Human, To Make Disease Prevention Easier

Called the Baseline Study, the Google project will initially collect anonymous genetic and molecular information from 175 people and later thousands more to create what the company hopes will be the fullest picture of what a healthy human being should be. The project won't be restricted to specific diseases and it will collect hundreds of different samples using a wide variety of new diagnostic tools. Then Google will use its massive computing power to find patterns, or "biomarkers," buried in the information. The hope is that these biomarkers can be used to understand the process of aging. Read more 
Microbes And Metabolites Fuel An Ambitious Aging Project

J. Craig Venter’s new company wants to improve human longevity by creating the world’s largest, most comprehensive database of genetic and physiological information. Human Longevity, based in San Diego, says it will sequence some 40,000 human genomes per year to start, and work its way up to 100,000 genomes per year. The company will also sequence the genomes of the body’s multitudes of microbial inhabitants, called the microbiome, and analyze the thousands of metabolites that can be found in blood and other patient samples. By combining these disparate types of data, the new company hopes to make inroads into the enigmatic process of aging. Read more
A Brief History Of The Immortality Business

Some of the earliest efforts at curing mortality occurred as far back as 2,500 B.C., when King Gilgamesh, in what’s now modern-day Iraq, believed a magic plant would grant him everlasting life. Fast forward to this year and both J. Craig Venter and Google’s push into the science of aging is the latest effort at significantly extending our lifespan. Google’s new company, called Calico, short for California Life Sciences Company, and Venter’s Human Longevity Inc. are likely the most serious such attempts ever. It may even be big business. Read more
The Global Burden Of Cancer

Cancer has long been a disease of rich countries since most people living long enough to face increased cancer risks live in the developed world. But the healthcare cost of these cancers, which show no sign of abating, places these established economies at increased risk of failure. Almost 60% of new cancer cases and 65% of deaths came from the developed world. According to the World Health Organization by 2025, a little less than 80 percent of all cancer deaths would happen in developed countries. Read more
Too Much Telomerase Can Be As Bad As Too Little

Aging is the gradual decline in function observed over time. Humans experience this age-related decline at a whole body or organ level and this decline leads to memory loss or weakening of muscle strength. But aging also takes place in individual cells. One of the central mechanisms responsible for the aging of cells is the shortening of telomeres. 
An enzyme called telomerase helps prevent the shortening of the telomeres. Telomerase thus acts as an anti-aging enzyme. Telomerase declines with age, but researchers warn that simply adding more telomerase won't solve our aging related decline. Read more
Upcoming Events
September 23-25, 2014 - MipTec 2014: Europe’s leading event for Drug Discovery and Life Sciences Research

August 21-23, 2014SENS Research Foundation is proud to present the Rejuvenation Biotechnology Conference: Emerging Regenerative Medicine Solutions for the Diseases of Aging. 

October 1, 2014Promoting longevity research on the 1st of October, the UN International Day of Older Persons

October 1-3, 2014
Eurosymposium on Healthy Ageing - A biannual conference that highlights the cutting-edge in the field of biogerontology, while facilitating a unique opportunity for researchers and advocates from around the world to meet.
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This newsletter was edited by Avi Roy

Copyright © 2014 The Longevity Reporter, All rights reserved.


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