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The Latest Updates from Frailty Science

Whether you are a researcher, clinician, student, policy maker, advocate, older adult, or caregiver—we hope you will find something interesting or useful on our site. We aim to provide a gateway to information for those seeking to learn more about frailty, vulnerability and resiliency in older adults. Below are the latest updates to the site.  Please visit for state-of-the-art information on frailty-related science and how it might impact health and wellness for older adults.

by: The Frailty Science Team

The sudden passing of Dr. Judy Kasper, a prominent expert in the study of disability in later life and its implications for older adults, their loved ones, and health care policies, struck all who knew her with feelings of sadness and shock. To celebrate Dr. Kasper as both a stellar scientist and a wonderful colleague and friend, we asked some of her collaborators to reflect on their work with her and the impact she had on their careers and lives. We have also summarized Dr. Kasper’s important role in facilitating frailty research in the National Health and Aging Trends Study. Continue Reading

Brian Buta, MHS
Project Administrator, Geriatric Medicine
Johns Hopkins University School of Medicin

Objective measures of function are critical to both the clinical care of older adults and to research on healthy aging and physical frailty. While telehealth had already been on the rise in recent years, the COVID-19 pandemic skyrocketed the use of remote and virtual assessments, creating an urgent need to adapt methods for patient care and research data collection to the new environments. Clinicians and investigators, struggling with the need to collect functional information remotely over video conferencing or by telephone, need guidance regarding the safety, feasibility and utility of various options and measures. Continue Reading

News & Announcements

New Content:  Mitochondrial Dysfunction and Frailty
One major feature of physical frailty is the lack of ‘energy’ often described fatigue by frail older adults. Early hypotheses of the underlying causes of physical frailty included the proposal that mitochondrial dysfunction led to low levels of energy production and ultimately to clinical features such as fatigue and low energy/activity levels (Wallace, 2011Loeb et al., 2005Wallace, 2010Wallace 2005Wallace, 2001). Over the past several years, studies into the biology of frailty have indeed identified features of mitochondrial decline that may ultimately contribute to physical frailty.  Continue Reading

Karen Bandeen-Roche To Give A Frailty Seminar on Feb. 9 at Noon ET
Dr. Karen Bandeen-Roche will present “Progression of Physical Frailty and The Risk of All-Cause Mortality” at the Frailty Seminar Series on February 9, 2022.  This seminar is offered at no cost, and certificates of attendance will be provided. Plus, AMA CMEs are available for those eligible.  Register here.  The series is sponsored by the Geriatric Research Education and Clinical Center. To learn more about the series, see our December blog at:

Copyright © 2022 Frailty Science, All rights reserved. is funded by the National Institute on Aging, P30-AG021334. ©2021

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