forum labo 2015March/Mars2015

Notre entreprise sera présente sur Forum LABO & BIOTECH du 31 mars au 2 avril 2015. Nous serons heureux de vous y accueillir afin de vous présenter notre savoir-faire et nos dernières innovations. Découvrez en exclusivité dans ce message nos deux posters !

Retrouvez nous sur le stand B84-C85 (Cliquez pour vous inscrire)

Our company will be present at Forum LABO & BIOTECH held in Paris, from March 31st to April 2nd, 2015. We will be happy to welcome you to present our expertise and our latest innovations. In preview in this message, discover the two posters we have prepared for the event.

Meet us at our stand B84-C85 (click here for free registration)

Development of co-culture Parkinson’s disease model using High Content Screening technology

Parkinson's disease (PD), adult neurodegenerative disorder, is caused by the death of dopamine neurons in the substantia nigra. High content screening (HCS) should allow finding new pathways involved in the onset of PD by screening molecules based on death phenotype. Rotenone, a chemical compound commonly used as pesticide, is well-documented as death inducer of dopamine neurons in the substantia nigra and allow to mimic PD in vitro and in vivo. Rotenone-induced degeneration of dopaminergic neurons may not be solely attributed to an impairment of neuronal mitochondrial complex I activity in the dopaminergic neurons but may also be boosted by the participation of the resident immune cells in the brain: the microglia cells. Effectively, various environmental factors may also work in concert to induce dopaminergic neurodegeneration and numerous studies have confirmed that neuroinflammation plays a critical role in the pathogenesis of neurodegenerative deseases, including PD.
To develop this assay, human neuroblastoma and mouse macrophagic cell lines in coculture were used, and rotenone was chosen as death inducer and phenotypic markers as Hoechst for nucleus and MAP2 for neurites analysis.
Furthermore, first assays in 3D cell co-culture show promising results and give us nice perspectives for the future. 

HepG2 cell model for genotoxicity and steatosis assessment

Early detection of toxic events induced by drug cantidats is mandatory in order to avoid late attrition in the process of R&D. Here we present two assays that can be done with the HepG2 human hepatoma cell line: genotoxicity assay (DNA double strand break) and steatosis.

Services

Explain us your requirements and we develop your assays to best meet your needs !

Our vision

To target complex diseases (as cancer and neurodegenerative diseases), more than one target are needed and screening on complex model is recommended.

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