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Serology
Issue 34  |   January 2017
ESL Biosciences, in partnership with Euroimmun AG, offer the most comprehensive range of diagnostic products for infectious serology
Zika NS-1 Based ELISA Provides Highly Sensitive and Specific Results

 

According to the article by K Steinhagen et al, the use of Zika-specific NS1 as the target antigen prevents cross-reactivity with antibodies against other flaviviruses.

The recent multicohort study reveals Zika NS1-based ELISA has “… a combined sensitivity (IgM/IgG) of 100% for RT-PCR-confirmed cases of ZIKV infection at 99.8% specificity. Among suspected ZIKV cases, the combined sensitivity amounted to 89.5%.”
"Cross-reactivity with high-level dengue virus antibodies was not detected"

(K Steinhagen et al, EuroSurveillance 2016 Dec 15;21(50))

Please refer to the article for more information on the study.

 

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