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 April 2015 Issue of FYDI - For Your Drug Information
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Co-edited by:
Pharm.D. Candidates: Tala Badwan & Kory Reeves
Gregory W. Smith, Pharm.D., Director, Drug Information Services

Greetings from the Drug Information Center at the University of Louisiana at Monroe School of Pharmacy

We hope you find this newsletter service helpful in staying well-informed. We continue to provide drug information services to healthcare professionals as a courtesy, so take a few moments to 
learn more about our Drug Information Services. 

Please contact us for assistance with your drug information needs by any of the following: 
          Phone 318.342.5501
          Email: druginfo@ulm.edu 
          Online Drug Information Requests

In this issue, read about current...
          FDA MedWatch and Other Safety Alerts
          News Items
          Drug Approvals
          New Guidelines


Learn more about our Drug Information Services

FDA MedWatch and Other Safety Alerts...


Mucinex Recall
RB, the manufacturer of Mucinex FAST-MAX is recalling liquid bottles of Mucinex products (list of affected drugs on website) due to incorrect drug labeling on the outside packaging.

View Here
 
Presence of Fake Medications Causes Global Pandemic

When it comes to medication sourcing, globalization has created a problem for many international physicians. Fraudulently made medications have appeared all over the world and are causing efficacy problems and in some instances death.

View Here
 
Topical NSAID May Cause Illness and Death in Household Pets
The FDA warns that people should limit their household pet’s exposure to topical NSAIDs that contain flurbiprofen as it may cause death and severe illness in these animals.

View Here


 
Baxter Recall: IV Solutions May Contain Particulates
Although no adverse events have been reported, Baxter Intl is recalling certain lots of IV solutions that were found to contain particulates.


View Here
 

 
FDA Recalls Products Made by Prescription Center Pharmacy in N.C.
Upon NCBOP (North Carolina Board of Pharmacy) inspection the Prescription Center Pharmacy was not able to prove their ability to provide sterile, stable and potent products. Health and Veterinary care specialists should check their stocks and avoid use of products sent out by the pharmacy.


View Here  
 

 
FDA Updates Warnings and Instructions of Feraheme 
The FDA has added a black box warning to Feraheme (ferumoxytol) to indicate a potentially fatal allergic reaction and has also added a contraindication for patients who are hypersensitive to IV iron.

View Here
 

 
Sofosbuvir/Antiviral Combo With Amiodarone May Cause Bradycardia 
It was found that any drug that contains sofosbuvir (used to treat Hepatitis C) when given with another antiviral and amiodarone (an antiarrhythmic) can cause significant bradycardia. The FDA is suggesting that these drugs not be used together.

View Here
 

 
Injectable Zyprexa Possibly Linked to Two Deaths
The FDA is investigating two deaths of schizophrenic patients after they were given appropriate doses of injectable Zyprexa. Deaths may be linked to the high levels of drug found in the patients’ blood.

View Here

 

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News Items...


Study Finds No Link Between Autism and Vaccinations
A retrospective study of children in the US has shown that there is no difference in the likelihood and age of onset of autism in children who are vaccinated versus children who are not vaccinated.
View Here

First Strains of H5N2 Bird Flu Found in US 
The fatal viral infection has been detected in a flock of  Wisconsin chickens. The disease can kill a flock in 48 hours and poultry producers are increasing their preventative measures to safeguard their stocks.
View Here
 
Acetaminophen May Blunt Emotions
Recent research has shown that happiness and positive emotions may be blunted by the use of acetaminophen.
View Here
 
Fruit and Tea Can Protect Health
Dietary studies suggest that polyphenols in green tea and apples may help prevent atherosclerosis and angiogenesis.
View Here
 
Muscle Supplements Linked to Testicular Cancer
Supplements containing creatinine or androstenedione may increase the risk of developing testicular cancer in males, especially if the supplements were taken before the age of 25. 
View Here
 
Military Dependants Have Lower Vaccine Rates
A survey suggests that children of military members seem to have lower rates of DTaP and Polio vaccination than their counterparts, which is possibly due to constant mobility and a lack of national vaccine registry.
View Here
 
Rotavirus Presence Decreases with Vaccine Use
Morbidity and Mortality Weekly Report  studies show that the effects of “herd immunity” are present in relation to the rotavirus vaccine. About 73% of children are vaccinated, causing the overall presence and duration of the disease to be much lower than before the vaccine was introduced in 2006.
View Here 
 
Poison Control Center Reports Increased Cases Involving New Designer Drug
A new synthetic drug - 251-NBOMe or “N-Bomb,” is becoming increasingly popular on the street according to the poison control center at Vanderbilt University.
View Here
 
Use of Selenide To Reduce Cardiac Damage After an MI
According to a preclinical study, selenide given as an IV immediately after cardiac arrest may reduce tissue damage by 90% due to prevention of ischemia and reperfusion.
View Here
 
Amphetamine-like Substance Found in Supplements 
BMPEA (an amphetamine isomer) has been found in the supplement Acacia. The FDA has asked manufacturers to recall all supplements with Acacia rigidula.
View Here
 
Fish Oil May Cause Resistance to Cancer Drugs
Fatty acids may interact with cisplatin and other anticancer drugs and cause chemoresistance.
View Here
 
Increase in Cipro-Resistant Shigellosis in the US 
Multidrug resistant shigellosis is brought to the US by travelers. Currently, strains of domestic shigellosis are resistant to ciprofloxacin, streptomycin, tetracycline, sulfamethoxazole and bactrim. 
View Here
 
Research Released on ADHD Treatment in Children
CDC releases information stating that the long term effects of psychotropic medications are unknown, however behavioral therapy is safe and has positive effects on a child’s development
View Here and Here
 
Beta-Lactam Monotherapy Noninferior in Uncomplicated Community Acquired Pneumonia
A cluster-randomized crossover study found beta-lactam monotherapy to be noninferior to both beta-lactam+macrolide therapy and fluoroquinolone mono therapy in treating uncomplicated CAP.
View Here
 
Black Seed May Decrease Adverse Events of Methotrexate 
Patients who supplement with or eat N.sativa may have better outcomes during use of methotrexate. 
View Here
 
ACIP Approves Meningococcal B Vaccine for High Risk Patients
The CDC’s Advisory Committee on Immunization Practice (ACIP) has approved the use of MB vaccine in patients who have weak immune systems, patients taking eculizumab, who are asplenic, are microbiologists or who are exposed to disease outbreaks.
View Here
 
FDA Gives Guidance on Labeling Abuse-Deterrent Opiates 
The FDA has supplied a document to help manufacturers develop tests and trials that prove a drug has abuse-deterrent properties.
View Here
 
Tricor Stimulates the Same Brain Receptors as Marijuana 
Researchers are suggesting that fenofibrate binds to the same cannabinoid receptors as marijuana. This may lead to future research on the use of fenofibrates for various pain, psychiatric and immune disorders.
View Here
 
New Ebola Vaccine Appears To Be Safe & Effective
A new Ebola vaccine developed by the Public Health Agency of Canada has shown safety and efficacy in creating Ebola-fighting antibodies.
View Here
 
A Medieval Eye Potion May be Effective Against MRSA
Scientists in England have rediscovered an ancient mixture of garlic, wine & oxgall that has antibacterial effects against MRSA.
View Here
 
Using Glyburide in Pregnancy Can Lead to Adverse Effects in Newborns 
Newborns whose mothers’ were treated with Glyburide for gestational diabetes were more likely to be at risk for respiratory distress, hypoglycemia, birth injury, and ICU admission upon birth.
View Here
 
Presidential Orders on Antibiotic Stewardship 
The White House has released the National Action Plan for Combating Antibiotic-Resistant Bacteria, a set of 5 goals with a 5 year timeline to help control the number of infections caused by multidrug resistant organisms.
View Here and Here


 

Drug Approvals...


Corlanor: Approved  for Heart Failure
The FDA has approved through fast-track a new drug named ivabradine (Corlanor) for chronic heart failure. The medication is the first in it’s class and is thought to work by decreasing the heart rate of patients.
View Here
 
Natpara Approved for Hypocalcemia due to Hypoparathyroidism
Natpara is now available for patients who do not have their hypocalcemia well-controlled with supplementation of calcium and vitamin D.
View Here
 
FDA Approves First Dry-Powder Short-Acting Beta-Antagonist Inhaler
Teva has received FDA approval for the ProAir RespiClick for use in acute asthma attacks in patients older than 12 years old.
View Here
 
FDA Approves Quadracel Vaccine
Sanofi has obtained approval for Quadracel vaccine for children 4-6 years of age for immunization against diphtheria, tetanus, pertussis and poliomyelitis.
View Here
 
New Drug Application Approved for Docetaxel Injectable 
Teikoku Pharma has received an NDA for a Docetaxel Injectable formula that contains no alcohol. The original formula reportedly caused adverse effects for patients sensitive to alcohol.
View Here
 
BioSolutions Gets Approval for Inhaled Anthrax Treatment 
Anthrasil is a new FDA approved antibacterial for the treatment of anthrax by neutralizing the bacterial toxins.
View Here


 

Guidelines...


Guidelines Released on Management of First Seizure in Adults
The Guideline Development Subcommittee of the American Academy of Neurology and the American Epilepsy Society released an evidence based guideline answering frequently asked questions such as risk of recurrence and selection and initiation of a treatment, for the management of unprovoked first seizure in adults.
View Here
 
U.S. Preventive Services Task Force: Breast Cancer Screening Draft Recommendations
For women between 50-74 years the recommended screening is still biannually. Women aged 40-49 years should be evaluated on an individual evaluation of risk vs. benefit. Currently there is a lack of data to recommend screening in women aged 75 years or older.
View Here and Here 

New HIV Treatment Guidelines Introduced
A summary of the major changes in the HIV guidelines is present here. They include an addition of  “recommended regimens” and the change of efavirenz from ‘recommended’ to ‘alternative’ due to tolerability and side effects.
View Here
 
Adult Sinusitis Management - Updated Guideline
Updated clinical practice guidelines released by the American Academy of Otolaryngology—Head and Neck Surgery Foundation includes a greater emphasis on chronic conditions affecting the treatment of sinusitis and more tools for patient education.
View Here
 
Updated Recommendations on the Management of Hypertension in Coronary Artery Disease
New expert consensus stresses the established blood pressure goal of 140/90 mmHg for patients without a previous event and 130/80 mmHg for those who have a previous event. 
View Here
 
Changes in Screening for Iron-Deficiency Anemia in Children & Pregnant Women
The draft guideline provides revised recommendations for screening asymptomatic children 24 months – 6 years for iron-deficiency anemia and for supplementing iron in asymptomatic pregnant women.
View Here
 
Canadian Recommendations on Primary Prevention and Treatment of Childhood Obesity 
According to these new recommendations, behavioral therapy has the most evidence for children and adolescents, and should be the mainstay of treatment over pharmacological or surgical interventions.
View Here


 
University of Louisiana at Monroe
School of Pharmacy

Drug Information Center

         318-342-5501
          druginfo@ulm.edu
          Online Drug Information Requests

The Louisiana Drug Information Center (DIC) is located on the first floor of the School of Pharmacy in the Bienville Building of the University of Louisiana at Monroe.
As a courtesy to healthcare professionals, we provide drug information services pertaining to the following areas:

Adverse Drug Events
Availability of Products
Complimentary and Alternative Medicine
Clinical Kinetics
Drug Dosage and Scheduling
Drug Identification
Drug Interactions
Drug Regulations/Laws
Drug Use Evaluation Support
Institutional Review Board Support
Investigational/Foreign Drugs
IV Compatibility
Laboratory Interpretation
Pharmacoeconomics
Pharmacy and Therapeutics Committee Support
Pregnancy and Lactation
Product Compounding
Therapeutic Drug Monitoring
Therapeutic Uses/Drugs of Choice
Toxicology
Travel/Health Information


The DIC provides information services to the healthcare professionals of the State of Louisiana. Additionally, this service is available to Medicaid providers through support from the Louisiana Medicaid Pharmacy Benefits Management Program.

Please contact us for assistance with your drug information needs by any of the following:
          Phone:  318-342-5501
          Email: druginfo@ulm.edu
          Online Drug Information Requests

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Thank you for reading the FYDI newsletter!

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University of Louisiana at Monroe School of Pharmacy
Drug Information Center
View previous issues of the FYDI newsletter.
Please send your comments and suggestions to 
druginfo@ulm.edu.

Disclaimer: No information source can replace clinical judgment applied to a specific case. Some of the drug therapy we write about will be outside the labeled indications for specific products. References will be provided when possible. Consult these references, product labeling, and/or give us a call if we can help with specific cases. This newsletter is supported by the University of Louisiana at Monroe School of Pharmacy and is not intended for commercial promotion.


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