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The Division of Hematology Newsletter 
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2017 Upcoming Conferences 
April-Duke Debates
July- ISTH
October-Kane Lecture
December-ASH

2017 Business Meetings
January 17th 9:30am DMP2W96
April 4th 9:00am DMP2W96
July 18th 9:00am DMP2W96
October 3rd 9:00am DMP2W96

Announcements

Congratulations...

Grace Lee, MD and  Nirmish Shah, MD

Congratulations to Dr. Brice Weinberg for being named as a Fellow  of the American Association for the Advancement of Science (AAAS).  Dr. Weinberg was one of three Duke Faculty recognized this year for their efforts toward advancing scientifically or socially distinguished science.  Dr. Weinberg is being recognized by the AAAS section on Medical Sciences for his distinguished contributions to the fields of immunology and hematology/oncology, “particularly for establishing the role of nitric oxide in inflammation, infectious disease, and leukemogenesis.” 



Welcome...
Luana Garcia, MD 


Dr. Luana Antunes Garcia is visiting the the Division of Hematology this month. She completed her medical degree at Universidade de Ribeirão Preto – UNAERP  in the state of Sao Paulo, Brazil. She then completed her Training internship in Internal Medicine at Hospital de Base in São José do Rio Preto, State of São Paulo from 2013 to 2015. She followed the with a Training Internship in Hematology and Hemotherapy at Hospital de Base in São José do Rio Preto, State of São Paulo which she will complete this year. Dr. Garcia is interested in benign hematology and will be spending time with us in our clinics and on consult rounds. We wish Dr. Garcia a warm welcome and look forward to her being with us during January. 



New Seminar Series...
UNC Thrombosis & Hemostasis Seminars


The Division of Hematology will be broadcasting the Friday UNC Thrombosis & Hemostasis Seminars at Duke.   The UNC seminar series features nationally/internationaly renowned basic scientific investigators in the field of hemostasis and thrombosis. The seminars are held several Friday mornings  a month from 11AM-12N.   If you wish to be added to the distribution list for upcoming seminars, please email John Ager: john.ager@duke.edu. Here is the Link to join the Friday Seminars: https://meet.ad.unc.edu/rcheng/MK36VDYZ
 


Congratulations to all who attended at ASH...

View More Photos Here

Marilyn Telen, M.D. and Anjali Advani, M.D.

Jacob Jacob Laubach, M.D., Krish Patel, and Mike Green, M.D. - Hem/Onc fellow Alum 

Gowthami Arepally, M.D. and Sandip Patel, M.D.
Chuck Greenerg, M.D. and Scott Berkowitz, M.D.
 

Hematology Holiday Party 2016 

View More Photos Here

Tuesday Hematology
Case Conferences

(Weekly from 8:00am-9:00am)
January 3rd, 2017
Gowthami Arepally, MD
Thomas Ortel, MD, PhD

 
January 10th, 2017

No Conference

January 17th, 2017

Erika Davis, M.D.

January 24th, 2017

Jason Zhu, M.D., Fellow 
Grace Lee, M.D.


January 31st, 2017
Ian J. Welsby, MB BS
Grace Lee, M.D. 
Away Dates
Faculty Away Dates
-
Staff Away Dates
-
Inpatient Consult Fellow Schedule  

1/4/-1/31 Jason Zhu, M.D. Fellow
Benign Hematology Outpatient Fellow Schedule
1/4-1/31 Shekeab Jauhari, M.D. Fellow
Medical Grand Rounds

For Grand Round Talks 
Click here

Caplacizumab for Acquired Thrombotic Thrombocytopenic Purpura. Peyvandi et. al. N Engl J Med 2016;374:511-22.
See Attached Article

High-dose dexamethasone vs prednisone for treatment of adult immune
thrombocytopenia: a prospective multicenter randomized trial.  Wei et. al.,
Blood. 2016;127(3):296-302
See Attached Article

 
“Postdoctoral Associate Position for Molecular Studies of Sickle Cell Nephropathy”

Position Title: Postdoctoral Associate

Department: Duke University School of Medicine, Department of Medicine

Job Description:  Funded by NIH, the project will focus on
dissecting the molecular basis of sickle cell disease nephropathy through the use of in vivo
zebrafish models, including construction of stable and inducible transgenic lines, as well as
transcriptomic analysis and therapeutic target discovery in those zebrafish lines.Read More...
Funding Opportunities
 

Kenneth M. Brinkhous Young Investigator Prize in Thrombosis
Grant Info: See attached PDF
Application Deadline:   Abstract submission October 19, 2016 through January 18, 2017.
Eligibility:  
  1) Applicants must be a member of the American Heart Association (membership number required to complete award application).  2) early-career (post-doctoral associates, fellows, or pre-tenured, junior faculty).  3) sustained research effort in any area related to thrombosis as evidenced by a peer-reviewed manuscript in the field. 
Award Amount: $1000 prize and $500 travel stipend to attend ATVB meeting
PDF Link 


Bayer Early Career Investigator Award
Grant Info: http://www.bayer-hemophilia-awards.com/awards/?view=early_career_investigator_award
Letter of Intent Deadline: November 30,2016
Application Deadline:    Feb/March 2017
Eligibility:
   New Faculty/New Investigator
Award Amount: $100,000/Yr x 2 YRS


Featured Clinical Trials

Study: Omeros study
Description: A phase 2, uncontrolled, two-stage, dose-escalation cohort study to evaluate the safety, pharmacokinetics, pharmacodynamics, immunogenicity, and clinical activity of oms721 in adults with thrombotic microangiopathies
Contact:  Angela Braswell  
Phone: 970-6134
Clinical trial #: NCT02222545

Study: Apixaban in SCD- (pi initiated)
Description: Impact of daily prophylaxis dose anticoagulation with a factor xa inhibitor (apixaban) in patients with sickle cell disease
Contact:   Sheila Lambert-Adams 970-0654 
Clinical trial #: NCT02179177

Study: Bayer Einstein Jr.- 
Description: Multicentre, open-label, active-controlled, randomized study to evaluate the efficacy and safety of an age- and body weight-adjusted rivaroxaban regimen in children with acute venous thromboembolism 
Contact:   Sheila Lambert-Adams
Phone: 970-0654   
Clinical trial #: NCT02234843

 
See More Studies 


 Got Blood?

 


27 year old Asian male who presented to the Duke ED with chronic abdominal pain.  He was found to have splenomegaly and a hypochromic, microcytic anemia.  Iron studies were well within normal range.  The CBC at presentation showed the following: 
 
                Patient                 Normal
Hgb        9.0 g/dL                13.7-17.3 g/dL
Hct         32%                        39-49%
RBC        5.37 x 1012/L       4.37-5.74 x 1012/L
MCH      16.8 pg                  26.5-34.0 pg
MCHC   28.5%                    31.5-36.3%
MCV      59 fL                       80-98 fL
RDW      24.2%                    11.5-14.5%
Plt           441                         150-450
WBC      5.9 x 109/L           3.2-9.8 x 109/L
 
His hemoglobin capillary electrophoresis (see image) shows two abnormal, fast-migrating hemoglobin peaks, at 13.3% and 1.0% of total hemoglobin, respectively.  He also has hemoglobins A, F, and A2, as marked on the plot.  The hemoglobin A2 level (0.8%) is significantly below normal range (2.2-3.2%). The hemoglobin F level is visible but not elevated (0.3%, normal <1%).
 
What are the two abnormal hemoglobin fractions, and what is his diagnosis?

 
Submit Answers Here
Publications
 
Heparin-induced thrombocytopenia: research and clinical updates.
Onwuemene O, Arepally GM.
Hematology Am Soc Hematol Educ Program. 2016 Dec 2;2016(1):262-268.
PMID: 27913490 [Unknown status]
 
Thrombospondin-1 Gene Polymorphism is Associated with Estimated Pulmonary Artery Pressure in Patients with Sickle Cell Anemia.
Jacob SA, Novelli EM, Isenberg JS, Garrett ME, Chu Y, Soldano K, Ataga KI, Telen MJ, Ashley-Koch A, Gladwin MT, Zhang Y, Kato GJ.
Am J Hematol. 2016 Dec 29. doi: 10.1002/ajh.24635. [Epub ahead of print] No abstract available.
PMID: 28033687 [PubMed - as supplied by publisher]
 
Etiology and complications of thrombocytopenia in hospitalized medical patients.
Fountain EM, Arepally GM.
J Thromb Thrombolysis. 2017 Jan 4. doi: 10.1007/s11239-016-1467-8. [Epub ahead of print]
PMID: 28054307 [PubMed - as supplied by publisher]

Other Info

HOW YOU CAN HELP
THE DIVISION OF HEMATOLOGY…

To discuss the many options for supporting the Division of Hematology, please contact L. Blue Dean (jake.pope@duke.edu; 919-385-3106)  or https://www.gifts.duke.edu/daa

Checks for the Division of Hematology can be mailed to:

Gifts to the Division of Hematology
Duke Medicine
Development and Alumni Affairs
710 W. Main Street, Suite 200
Durham, NC 27701

Copyright © 2017 Duke Hematology, All rights reserved.


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